Before starting Zhewitra, certain precautions must be considered. Individuals with cardiovascular conditions, such as severe heart disease or recent heart attack, should consult their doctor, as sexual activity itself can pose risks. Additionally, Zhewitra should not be used in conjunction with nitrate medications, commonly prescribed for chest pain, as this combination can cause a dangerous drop in blood pressure. Drug interactions are another important consideration. It is crucial to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.

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